患有白血病的患者的非结核菌菌 (NTM) 感染:单个中心病例系列
Jennifer Marvin-Peek1, Koji Sasaki2, Dimitrios P Kontoyiannis3
1Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Frontiers in medicine
|August 16, 2024
概括
非结核菌菌 (NTM) 感染很少发生,但在白血病患者中可能危及生命. 早期的酸快细菌 (AFB) 培养对于及时诊断和治疗这些感染至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 微生物学 微生物学
背景情况:
- 白血病患者因疾病和化疗而面临严重的免疫抑制.
- 在白血病患者中,非结核性真菌菌菌 (NTM) 感染的患病率和临床特征尚不清楚.
研究的目的:
- 调查白血病患者中NTM感染的发生率和临床表现.
- 突出早期诊断和在这个脆弱人群中适当管理NTM的重要性.
主要方法:
- 对29743名白血病患者的病历进行了回顾性审查.
- 通过酸快菌根 (AFB) 培养物识别NTM感染.
- 分析临床数据,包括感染类型,传播和患者结果.
主要成果:
- 在白血病患者中发现了6例NTM感染病例.
- 四名患者患有血液感染,五名患有传播疾病.
- 一名患者出现了不寻常的扩散性纤维炎/肌炎;两名患者死于NTM感染.
结论:
- NTM感染对白血病患者来说是一种罕见但严重的威胁.
- 早期AFB培养对于迅速的抗微生物和白血病导向治疗至关重要.
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