得到良好控制的孕产妇炎性肠病不会增加子女神经认知结果查异常的风险
Ralley E Prentice1,2,3, Rod W Hunt4,5,6, Alicia J Spittle7,8
1Department of Gastroenterology, Monash Health, Melbourne, VIC, Australia.
孕期孕产妇的炎症性肠病 (IBD) 对婴儿的神经发育构成风险. 新生儿MRI和基于应用程序的运动评估是可行的查工具,在高危婴儿的早期检测方面显示出有希望的结果.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 怀孕期间母亲的炎症会增加后代患神经发育障碍的风险.
- 早期诊断和干预对于改善儿童运动和认知功能至关重要.
- 新生儿大脑MRI和通用运动评估 (GMAs) 预测了不良的神经认知结果,但通常用于高风险婴儿.
研究的目的:
- 评估使用新生儿大脑MRI和基于应用程序的GMA用于在子宫内暴露于母亲炎性肠病 (IBD) 的婴儿的神经认知查的可行性.
- 评估这些方法在人口中具有预测价值,其中脑的风险尚未明确定义.
主要方法:
- 对患有IBD的孕妇进行前性研究,在三个月内从临床和生物化学上进行评估.
- 新生儿大脑MRI在经过校正后6-12周进行.
- 基于应用程序的GMA (BabyMoves) 在12-16周年龄记录,使用验证的评分系统进行盲目评估.
主要成果:
- 招募了40/53个受邀的母婴双;产前C反应蛋白升高<13%.
- 5/37名新生儿的MRI显示了偶尔的异常;在验证的严重异常得分上,没有异常.
- 3/35个GMA异常,其中有一个临床显著的异常;其中2/3的婴儿在子宫内暴露于严重活跃的IBD.
结论:
- 新生儿大脑MRI和GMA可用于IBD母亲的婴儿的神经认知查.
- 这些查干预措施可能特别有价值,因为当脑风险不清楚时,家长不愿意进行繁的测试.
- 需要进行更大的研究来分层风险,但目前的数据对怀孕期间IBD缓解的妇女来说令人放心.
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