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Updated: Jun 16, 2025

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
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A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors

Published on: August 17, 2019

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针对药物发现的ATM的小分子抑制剂:当前的研究和潜在的前景

Chunlin Qian1, Xiaoxue Li2, Jifa Zhang1,3

  • 1Department of Respiratory and Critical Care Medicine and Targeted Tracer Research and Development Laboratory and Institute of Respiratory Health and State Key Laboratory of Respiratory Health and Multimorbidity and Laboratory of Neuro-system and Multimorbidity, West China Hospital, Sichuan University, Chengdu 610041, Sichuan China.

Journal of medicinal chemistry
|August 16, 2024
PubMed
概括

突变的telangiectasia (ATM) 缺血症对DNA修复和应激反应至关重要,其失调与癌症和神经退行有关. 这一观点审查了用于治疗这些疾病的临床试验中的ATM抑制剂.

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