杜皮卢马布与长期多囊性鼻炎的鼻外科手术的比较有效性:系统性审查和元分析
Do Hyun Kim1, Gulnaz Stybayeva2, Se Hwan Hwang3
1Department of Otolaryngology - Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
American journal of rhinology & allergy
|August 16, 2024
概括
功能性内镜外科手术 (FESS) 和dupilumab在慢性鼻炎与鼻多重症 (CRSwNP) 的长期有效性相似. 杜皮卢马布在一年后提供了更大的嗅觉改善.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性鼻炎与鼻多重症 (CRSwNP) 通常需要手术干预,当医疗治疗失败时.
- 了解生物药物和手术的比较疗效对于优化CRSwNP管理至关重要.
研究的目的:
- 为了比较dupilumab与功能性内镜外科手术 (FESS) 在治疗CRSwNP的长期疗效.
- 评估结果,包括鼻塞,息肉负担,生活质量和嗅觉.
主要方法:
- 对4项涉及724名CRSwNP患者的研究进行了系统审查.
- 结果的比较:鼻塞积分 (NCS),中鼻结局测试-22 (SNOT-22),宾夕法尼亚大学气味识别测试-40 (UPSIT-40) 和鼻积分 (NPS).
- 使用纽卡斯尔-太华规模评估的偏差风险.
主要成果:
- 与FESS相比,dupilumab表现出更好的鼻塞得分,但与FESS相比,鼻多得分更差.
- 最初,SNOT-22的分数有利于FESS,但在一年内变得相似.
- 嗅觉功能 (UPSIT-40) 显示了类似的趋势,杜皮卢马布在一年后领先.
结论:
- 在短期内,FESS的疗效优于dupilumab.
- 在治疗后一年,FESS和dupilumab均显示出类似的整体有效性.
- 杜皮卢马布在一年后的嗅觉功能得到了更大的改善.
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