应用的重复和电极与组织的接触导致使用脉冲场除循环可变循环导管的更深层损伤
Luigi Di Biase1, Jacopo Marazzato1,2, Tara Gomez3
1Department of Cardiology, Montefiore Medical Center, 111 E 210th Street, Bronx, NY 10467, USA.
概括
脉冲场切除 (PFA) 损伤深度随着重复应用和更好的导管接触而增加. 有效的PFA依赖于生物物理学,而不仅仅是电图信号损失.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 医疗器械 医疗器械
背景情况:
- 脉冲场切除 (PFA) 是一种新的非热法,用于准心律失常.
- 在肺静脉中PFA后电图 (EGM) 信号的立即消失并不能保证转移性损伤的形成.
研究的目的:
- 调查应用重复和导管组织接触对PFA期间病变形成的影响.
- 为了确定PFA终点是否与生物物理有关,而不是EGM衰减.
主要方法:
- 采用圆环PFA导管,以不同的接触力进行反复的能量应用.
- 采用植物土豆和跳动心脏的猪心室模型来评估病变深度和连续性.
- 评估了应用重复,接触力和导管重新定位的影响.
主要成果:
- 损伤的形成取决于应用的重复和导管与组织的接触.
- 在猪心室中,堆叠的应用产生了比单次应用 (3.5 ± 0.7 mm) 更深的病变 (4.4 ± 1.3 mm).
- 在植物模型中,增加了导管-组织接触显著提高了病变深度和连续性.
结论:
- 无论是重复的PFA应用和导管接触,都会独立地导致更深层的病变形成.
- 有效的PFA终点是由能源输送的基础生物物理决定的,而不仅仅是EGM信号减弱.
相关概念视频
Force On A Current Loop In A Magnetic Field
3.7K
Magnetic forces on wires carrying current are most frequently applied in motors. A DC motor is a device that converts electrical energy into mechanical work. In motors, wire loops are enclosed in a magnetic field. When current flows through the loops, the magnetic field applies torque, which causes the shaft to rotate. The direction of the current is reversed once the loop's surface area is lined up with the magnetic field, causing a constant torque on the loop. During the process, commutators...
3.7K
Induced Electric Fields: Applications
2.7K
An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...
2.7K
Applications of RC Circuits
5.1K
A relaxation oscillator is one of the applications of RC circuits. A neon lamp relaxation oscillator comprises a capacitor, a resistor, a voltage source, and a lamp. The lamp acts like an open circuit, with infinite resistance until the potential difference across the lamp reaches a specific voltage. At that voltage, the lamp acts like a short circuit with zero resistance, and the capacitor discharges through the lamp, thus producing light. Once the capacitor is fully discharged through the...
5.1K
Node Analysis for AC Circuits
806
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
806
Fatigue
1.1K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.1K
Laminar Flow
2.1K
Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
2.1K


