与健康结果相关的ICU中的饮食蛋白质
Danielle E Bear1,2,3, Matthew J Summers4,5, Lee-Anne S Chapple4,5
1Department of Nutrition and Dietetics.
在重症监护中摄入较高的蛋白质可能有助于保持肌肉质量,但会带来风险. 需要进一步的研究来平衡特定患者群体的益处与潜在危害.
科学领域:
- 关键护理医学 关键护理医学
- 营养科学 营养科学
- 临床研究是临床研究.
背景情况:
- 目前的重症监护营养指南建议蛋白质剂量高于健康个体.
- 这些建议源于增加蛋白质可以减轻重症患者的肌肉损失的理由.
- 支持这些较高剂量的证据历来质量较差.
研究的目的:
- 审查蛋白质在重症患者中的机械作用.
- 详细介绍最近临床试验发现的蛋白质剂量和健康结果.
- 讨论试验结果的解释,并概述未来的研究方向.
主要方法:
- 对危急疾病中蛋白质代谢的机械数据的审查.
- 对最近对蛋白质补充剂的大规模临床试验结果的分析.
- 综合从系统性审查和元分析中发现的结果.
主要成果:
- 最近的试验表明,在特定的患者亚组中,较高的蛋白质剂量可能会对患者造成潜在的危害.
- 在元分析中,较高的蛋白质剂量已被证明可以减轻肌肉损失.
- 像尿素:肌素比率这样的生物标志物可以帮助监测危害.
结论:
- 未来的研究应该前性地确定生物标志物,表明高剂量蛋白质对人体有害.
- 调查增强蛋白质有效性的因素至关重要.
- 为了优化蛋白质疗法,平衡肌肉保护的好处与潜在风险是必不可少的.
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