桑托菲洛米切斯 (Xanthophyllomyces dendrorhous) 是一种安全的食补充剂,具有强大的抗氧化剂防御增强活动
Yanli Wang1, Yan Piao2, Nan Chen1
1College of Food Science and Engineering, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
Journal of agricultural and food chemistry
|August 16, 2024
概括
桑托菲洛米切斯 (Xanthophyllomyces dendrorhous) (X. dendrorhous) 是安全的消费,没有观察到毒性在老鼠,即使在高剂量. 这种红酵母表现出有益的抗氧化作用,并可能增强免疫功能.
科学领域:
- 营养科学 营养科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 桑托菲洛米塞斯 (Xanthophyllomyces dendrorhous) (X. dendrorhous),以前称为法菲亚 (Phaffia rhodozyma),是一种红色酵母,以其丰富的胡卜素含量而闻名,特别是阿斯塔丁.
- 阿斯塔丁具有显著的抗氧化特性和潜在的健康益处.
- 关于食用X. dendrorhous.安全性的研究有限.
研究的目的:
- 通过对老鼠的急性和次慢性毒性研究,评估食用X. dendrorhous的安全性.
- 为了研究X. dendrorhous的体内抗氧化活性.
主要方法:
- 急性毒性研究:Sprague-Dawley大鼠接受了X. dendrorhous单次口服剂量 (高达12g/kg体重).
- 亚慢性毒性研究:老鼠接受了90天的含有0%,2.5%,5%,10%或20%X. dendrorhous的饮食.
- 评估包括监测行为,体重,食物摄入量,以及分析血液,尿液,器官和血清抗氧化活性.
主要成果:
- 急性毒性研究表明LD50大于12g/kg体重,没有观察到任何不良影响.
- 亚慢性研究表明,对体重,食物摄入量,血液/尿液参数或器官组织学没有定期的毒性影响.
- 高剂量的雄性大鼠的高甘油三水平与饮食脂肪含量增加有关.
- 极高剂量组白细胞数量的增加表明潜在的免疫增强.
- 观察到谷氨过氧化酶 (GSH-Px) 活性和ABTS激素清除能力显著增加.
- 减少马隆迪阿尔海德 (MDA) 含量表明脂质过氧化减少.
结论:
- 桑托菲洛米切斯 (Xanthophyllomyces dendrorhous) 没有毒性作用,可以高剂量食用.
- 酵母在体内表现出显著的抗氧化活性,由增加的GSH-Px和ABTS基因清除所证明.
- 消费X.dendrorhous可能提供免疫增强的好处,并减少氧化应激.
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