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Updated: Jun 16, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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YAP1状态定义了两种内在的LCNEC亚型,具有明显的分子特征和治疗脆弱性

C Allison Stewart1, Lixia Diao2, Yuanxin Xi2

  • 1Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.

Clinical cancer research : an official journal of the American Association for Cancer Research
|August 16, 2024
PubMed
概括

大细胞神经内分泌癌 (LCNEC) 基于YAP1表达有两种亚型. 高YAP1的LCNEC对MEK/AXL抑制剂有反应,而低YAP1的LCNEC可能受益于SCLC类疗法.

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