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确定眼部主观反应的最小临床重要差异 (MCID)

Maria Navascues-Cornago1, Sarah Guthrie2, Philip B Morgan1

  • 1Eurolens Research, Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Translational vision science & technology
|August 16, 2024
PubMed
概括

隐形眼镜 (CL) 主观反应的最小临床重要差异 (MCID) 在0-100视觉模拟量表 (VAS) 上始终在7个单位左右. 这些MCID值在不同的反应和研究设计中对于软CL佩戴者来说是相似的.

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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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