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Updated: Jun 16, 2025

Quantifying Agonist Activity at G Protein-coupled Receptors
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Published on: December 26, 2011

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pKaGPCRs的计算:理解受体激活中的质突状态

Carlos A V Barreto1,2, João N M Vitorino3, Pedro B P S Reis3

  • 1PhD Programme in Experimental Biology and Biomedicine, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Casa Costa Alemão, 3030-789 Coimbra, Portugal.

Journal of chemical information and modeling
|August 16, 2024
PubMed
概括

一个关键残留物的质子化,酸2.50,对于激活一些G蛋白结合受体 (GPCRs) 至关重要. 这种与质子结合的激活机制似乎是特定于某些GPCRs,如A2AR和B2AR.

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