饮食中的糖化化合物 - 对人类健康的影响
Michael Hellwig1, Patrick Diel2, Gerhard Eisenbrand3
1Chair of Special Food Chemistry, Technische Universität Dresden, Dresden, Germany.
Critical reviews in toxicology
|August 16, 2024
概括
通过梅拉德反应形成的食糖化化合物与不良健康影响没有令人信服的联系. 这次审查没有发现强有力的证据表明,食品基的糖化化合物对营养有风险.
科学领域:
- 食品化学和毒理学 食品化学和毒理学
- 营养科学 营养科学
- 公共卫生风险评估 公共卫生风险评估
背景情况:
- 糖化化合物通过梅拉德反应在内源性和食品中形成.
- 人们担心饮食中的糖化化合物可能会给健康带来风险.
- 这项研究系统地审查了有关糖化化合物和疾病的证据.
研究的目的:
- 总结关于糖化化合物的形成,发生,暴露和毒性的数据 (A部分).
- 系统地评估定义的糖化化合物的饮食摄入量与各种疾病 (B部分) 之间的潜在关联.
- 评估消费食品糖化化合物对健康有害影响的总体证据.
主要方法:
- 在PubMed,Scopus和Web of Science进行了系统的文献搜索.
- 包括与特定的糖化化合物,疾病,食物,营养和饮食相关的关键词.
- 对253个获取的出版物应用了质量标准,选择了192个用于评估.
主要成果:
- 对于每个评估的健康影响,确定了有限的人类,动物和体外研究.
- 人类研究受到小样本大小,短时间和混因素的影响.
- 动物研究表明,高剂量的二碳烯化合物对葡萄糖耐受性,胰岛素耐受性,心血管和脏有影响.
结论:
- 没有令人信服的证据支持饮食中的糖化化合物与不良健康影响之间的因果关系.
- 目前的数据不确定食品衍生的糖化化合物的显著营养风险.
- 可能需要进一步的研究来澄清潜在的低剂量效应.
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