带有主观认知衰退的社区居民内皮功能,生命参数和认知表现之间的关系:一项六个月的随访观察研究
Johannes Sittig1, Lena Pickert1, Hannah Weigert1
1Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Journal of Alzheimer's disease : JAD
|August 16, 2024
概括
心率 (HR),心率变化 (HRV) 和增强指数 (AI) 与主观认知衰退 (SCD) 的老年人认知表现相关. 这些生命体征可能有助于早期诊断神经退行性疾病.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
背景情况:
- 老化中的认知衰退与内皮功能障碍有关.
- 在轻度认知障碍 (MCI) 开始之前的血管性能数据有限.
研究的目的:
- 探索内皮功能,重要参数和经历主观认知衰退 (SCD) 的老年人认知表现之间的关联.
主要方法:
- 45名65岁以上的SCD成年人接受了老年病学评估 (多维预后指数 - MPI),神经心理测试和外围动脉度测试 (EndoPATTM2000).
- 评估了内皮的灵活性和重要参数.
- 六个月后,进行了通过电话管理的MPI (TELE-MPI).
主要成果:
- 15名参与者显示得分表明MCI.
- 在心率 (HR) 和Trail Making Test A (TMT A),心率可变性 (HRV) 和TMT B,HRV低频功率 (LF) 和迷你营养评估短形式以及增强指数 (AI) 和CogState检测测试之间观察到显著的相关性.
结论:
- 心率 (HR),心率变化 (HRV) 和增强指数 (AI) 与SCD和疑似MCI患者的认知表现有关.
- 在这个队列中,内皮的灵活性与认知表现没有显著的关联.
- 这些重要参数可以作为老年人群中神经退行性疾病的早期临床生物标志物.
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