婴儿时期的伊索尼亚齐德预防性治疗不会对暴露于艾滋病毒的未感染儿童的生长产生不利影响:随机对照试验数据的二次分析
Ashenafi Shumey Cherkos1, Sylvia M LaCourse2,3,4, Daniel A Enquobahrie2
1Department of Population and Community Health, School of Public Health, University of North Texas Health Science Center, Fort Worth, Texas, United States of America.
PloS one
|August 16, 2024
概括
伊索尼亚预防疗法 (IPT) 在头两年没有影响婴儿的生长. 这项针对暴露于艾滋病毒的未感染婴儿的研究发现,群体之间体重与年龄或身高与年龄的z-score没有显著差异.
科学领域:
- 儿童传染病 儿童传染病
- 全球儿童健康 儿童健康
- 预防结核病的预防措施
背景情况:
- 伊索尼亚兹预防疗法 (IPT) 降低了结核病 (TB) 的风险.
- IPT对婴儿生长的长期影响尚未得到充分证实.
- 这项研究评估了IPT对暴露于艾滋病毒的未感染婴儿 (HEU) 没有已知结核病暴露的成长的影响.
研究的目的:
- 评估异化预防疗法 (IPT) 对婴儿生长的影响.
- 为了比较接受IPT的HIV暴露未感染婴儿与对照组的生长轨迹 (体重对年龄z-score [WAZ]和身高对年龄z-score [HAZ]).
- 为了分析24个月龄前的生长结果.
主要方法:
- 一项非盲目的随机对照试验 (RCT) 涉及298名未感染的肯尼亚艾滋病毒暴露的婴儿.
- 婴儿每天接受12个月的异化 (IPT手臂) 或没有干预 (对照手臂).
- 治疗意图线性混合效应模型被用来比较WAZ和HAZ之间的小组,直到24个月的年龄.
主要成果:
- 在IPT和对照组之间没有观察到WAZ或HAZ的显著差异.
- 两组都经历了WAZ和HAZ的下降,男性婴儿的HAZ下降更大.
- 在IPT手臂中的婴儿显示,每月体重对身高z-score (WHZ) 的增加略高,增加了24个月.
结论:
- 对暴露于艾滋病毒的未感染婴儿进行的异化预防疗法 (IPT) 在生命的头两年没有显著影响生长结果.
- 在接受IPT的婴儿和对照组中的婴儿之间,体重相对于年龄和身高相对于年龄的z-score的生长轨迹类似.
- 进一步的研究可能会探索潜在的微妙效应或超过24个月的长期影响.
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