清醒与睡眠对帕金森病的深度大脑刺激:一个全面的系统性审查和元分析
Seyed Farzad Maroufi1,2, Mohammad Sadegh Fallahi1,2, Saba Hosseinzadeh Asli1,2
11Neurosurgical Research Network (NRN), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Journal of neurosurgery
|August 16, 2024
概括
帕金森病的深度大脑刺激 (DBS) 显示出类似的运动改善,无论是清醒还是睡觉. 睡眠时DBS的认知分数略有改善,但手术事件更多,而清醒时DBS的心理副作用更多.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 运动障碍 运动障碍
背景情况:
- 深度大脑刺激 (DBS) 是晚期帕金森病 (PD) 的关键治疗方法.
- 关于最佳的手术方法存在争议:清醒与睡眠DBS.
- 本综述全面比较了这两种DBS技术.
研究的目的:
- 对帕金森病的清醒与睡眠DBS进行系统的审查和比较.
- 分析临床结果,不良事件和特定患者亚组的差异.
主要方法:
- 系统审查PubMed,Scopus,科学网络和科克兰图书馆.
- 包括31项研究,包括2563名帕金森病患者.
- 分析和偏差风险评估.
主要成果:
- 在清醒和睡眠DBS之间,可比的运动改善和药物减少.
- 睡眠DBS显示出更好的认知和生活质量得分,但更多的外科手术不良事件.
- 醒着的DBS与更多的肺脑病和心理障碍有关.
结论:
- 无论是清醒的还是睡眠的DBS都为帕金森病提供了类似的临床结果.
- 关键的区别在于特定的不良事件和通过.
- 患者偏好,外科医生经验和成像可用性指导DBS技术的选择.
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