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多发性硬化症中运动和神经纤维光链之间的相互作用:系统审查和元分析

Hassan K Salamatullah¹, Ahmed Alkhiri¹, Suzana Ezzi¹

¹College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.

Multiple sclerosis and related disorders

|August 16, 2024

概括

结构化炼计划显著降低了多发性硬化症 (pwMS) 患者的神经纤维光链 (NfL) 的水平. 像 Pilates 这样的特殊训练和在家进行的炼显示出显著的减少,这表明炼辅助在管理神经轴损伤生物标志物.

科学领域:

神经学神经学
运动科学运动科学
生物标志物研究生物标志物研究

背景情况:

众所周知,运动可以改善多发性硬化症 (pwMS) 患者的症状管理和功能.
运动对神经纤维光链 (NfL) 的影响,这是MS中神经轴突损伤的生物标志物,由于有相互矛盾的证据,仍然不清楚.
本研究研究了运动干预措施与pwMS中NfL水平之间的关系.

研究的目的:

评估运动对多发性硬化症 (pwMS) 患者神经丝光链 (NfL) 水平的影响.
确定结构化炼计划是否可以减少MS患者神经轴突损伤的生物标志物.

主要方法:

在主要数据库 (Medline,CENTRAL,Embase,Web of Science) 进行了系统的文献搜索,直到2024年3月.
包括的研究比较了NfL水平变化和运动前后干预措施与对照组.
使用随机效应模型计算标准化平均差异 (SMD) 以 95% 的置信区间.

主要成果:

七项涉及222篇文章的研究符合纳入标准.
结构化的运动显著降低了血液中的NfL水平 (SMD -0.55;95%CI -1.00, -0.09).
户外Pilates和家庭训练显示了显著的NfL减少 (SMD分别为-2.08和-1.46),而8周的炼显示了显著的下降 (SMD -0.73). 对照组没有显示显著的NfL变化.

结论:

运动干预显示了初步证据,可以降低 pwMS. pwMS 中的血NfL水平.
特定的运动类型,如皮拉塞斯和家庭训练,似乎特别有效.
需要进一步进行高质量的研究来证实这些发现,并将运动作为减少MS中神经轴损伤的治疗策略.

关键词:

运动运动运动.进行元分析分析.多发性硬化症是多发性硬化症.神经光纤光链链的使用方法电阻电阻电阻电阻电阻电阻培训培训培训培训培训

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