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饮食中的黄酸盐摄入量和与激素相关的癌症风险:基于人口的前性队列研究

Fubin Liu¹, Jingyi Xu², Xixuan Wang¹

¹Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|August 16, 2024

概括

饮食中的黄类药物可能会降低与激素相关的癌症 (HRCs) 的风险,包括乳腺癌和卵巢癌. 炎症,激素和氧化应激的生物标志物部分解释了这些保护作用.

科学领域:

营养流行病学营养流行病学
在瘤学瘤学.
生物化学生物化学

背景情况:

食中的黄类化合物具有抗癌特性,通过调节激素,炎症和氧化应激,可能会影响与激素相关的癌症 (HRCs).
了解黄类药物摄入量与HRC风险之间的特定关联以及潜在的生物机制对于公共卫生至关重要.

研究的目的:

调查饮食中的黄酸盐摄入量与患各种与激素相关的癌症 (HRCs) 的风险之间的关联.
探索与炎症,荷尔蒙和氧化应激相关的血液生物标志物是否调解了黄类消费和HRC风险之间的关系.

主要方法:

一项前性队列研究利用了187350名英国生物库参与者的数据,详细的饮食评估 (24小时回忆) 和基线血液生物标志物测量.
使用因果特异的考克斯比例危险模型来估计黄类药物摄入量和HRC风险的危险比率 (HRs) 和95%置信区间 (CI).
调解分析被用来评估血液生物标志物在观察到的关联中的作用.

主要成果:

较高的总黄类药物摄入量与乳腺癌 (HR 0.89; 0.80-0.99),卵巢癌 (HR 0.68; 0.50-0.92) 和整体女性特异性癌症的风险降低有关.
特定的子类,包括黄醇和氨酸,显示与女性特异性癌症风险的反向关联. 安托西亚尼丁摄入量与前列腺癌风险有积极联系,而异黄摄入量与甲状腺癌风险相反相关.
发现炎症,激素和氧化应激的生物标志物调解了黄类药物摄入量与女性特异性癌症和前列腺癌风险之间的关联.

结论:

在一般人群中,饮食中的黄类药物在预防与激素相关的癌症 (HRCs) 中发挥着重要作用.
这些发现提供了流行病学证据,支持将黄类药物纳入预防癌症的饮食指南.

关键词:

血液中的生物标志物黄类子类的亚类.黄类化合物黄类化合物与荷尔蒙相关的癌症英国生物银行

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