精神分裂症谱系障碍患者的结构性大脑差异,有和没有听觉口头幻觉
Alexander Tobias Ysbæk-Nielsen1, Rubina Fray Gogolu1, Maya Tranter1
1Department of Psychology, University of Copenhagen, Denmark.
精神分裂症谱系障碍 (SSD) 与灰色物质体积 (GMV) 的减少有关. 在SSD患者中,听觉语言幻觉 (AVH) 特别与左Heschl减少有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症谱系障碍 (SSD) 是一种严重的精神健康状况,其特点是灰色物质体积 (GMV) 显著减少.
- 听觉语言幻觉 (AVH) 是SSD的核心症状,但其潜在的神经机制尚未完全理解.
- 之前的研究始终表明,SSD群体的GMV减少,需要进一步调查特定的症状相关性.
研究的目的:
- 调查SSD和健康对照 (HC) 个体之间的灰质体积 (GMV) 差异.
- 为了在SSD队列中确定与听觉语言幻觉 (AVHs) 相关的GMV变化.
- 探索精神分裂症谱系障碍患者中AVH严重性的神经相关性.
主要方法:
- 利用以前发表的71名成年参与者的结构性脑成像数据 (46名SSD,25名HC).
- 评估了对皮层区域,前带皮层 (ACC),上椎 (STG),海马和胸膜的GMV的群体差异.
- 在SSD患有 (AVH+) 和没有 (AVH-) 幻觉的患者之间比较左Heschl's gyrus (HG) 的体积.
主要成果:
- 与HC相比,SSD患者在皮质,ACC,STG,海马和沙拉米中表现出减少的GMV.
- 与没有AVH (AVH-) 的人相比,患有AVH (AVH+) 的个体表现出明显减少的左侧血球体积.
- 一个右侧的腹部前额集群与AVH严重程度有独特的关联.
结论:
- 这项研究证实了SSD种群中广泛的转基因病毒减少.
- 研究结果表明,AVH与语言处理区域的结构变化有关,特别是左侧的Heschl's gyrus.
- 结果强调了语言网络改变在精神分裂症谱系障碍中听觉语言幻觉病理生理学的作用.
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