NCCN指导方针®洞察:直肠癌,版本3.202424 年
Al B Benson1, Alan P Venook2, Mohamed Adam2
1Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Journal of the National Comprehensive Cancer Network : JNCCN
|August 16, 2024
概括
优化直肠癌治疗包括平衡治疗目标与功能结果. 最近的更新包括早期疾病的新选择和完整响应者的非手术管理.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 结直肠癌的治疗需要复杂的决策,平衡治疗意图,功能结果 (肠道/泌尿器官) 和生活质量.
- 远端直肠癌在实现治疗疗法并对生活质量产生最小影响方面存在独特的挑战.
- 直肠癌的盆腔复发风险高于结肠癌,局部复发的疾病与预后不佳有关.
研究的目的:
- 详细介绍国家综合癌症网络 (NCCN) 关于直肠癌的指导方针的最新更新.
- 突出对直肠癌患者治疗策略的进步.
- 为临床医生提供有关新疗法选择和管理方法的信息.
主要方法:
- 审查最近的临床试验数据和对直肠癌管理指南的修订.
- 包括用于早期直肠癌的内镜下粘膜剖析.
- 对全新辅助疗法 (TNT) 和非手术治疗 (观察和等待) 策略的评估.
主要成果:
- 现在,内镜下粘膜切割是选择早期直肠癌的一个选择.
- 全新辅助疗法方法的更新是基于最近的临床试验结果.
- 对于临床完整响应新辅助疗法的患者,建议采用非手术治疗方法 ("观察和等待").
结论:
- 对于直肠癌,建议采用多学科的方法,仔细选择患者和顺序的多模式疗法.
- 最近的NCCN指南更新为早期疾病和后新辅助疗法管理提供了扩展的选择.
- 这些更新旨在提高治疗效率,同时保持直肠癌患者的功能结果和生活质量.
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