在食后和禁食状态中的急性被动间歇性和持续性低氧症期间食欲的变化:对四项基于实验室的随机交叉试验的综合分析
Nicholas Goulet1, Renée Morin1, Caroline Marcoux1
1Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Appetite
|August 16, 2024
概括
由于高海拔或睡眠呼吸暂停,急性低氧症对食欲有不同的影响. 观察到食欲下降,但并不总是临床显著,根据条件和饮食状态而异.
科学领域:
- 身体生理学 身体生理学
- 高度医学 高度医学
- 睡眠医学 睡眠医学
背景情况:
- 低氧症,以低氧度为特征,发生在高空暴露 (连续) 或像阻塞性睡眠呼吸暂停 (OSA;间歇性) 等条件下.
- 现有研究表明低氧化症会降低食欲,但对急性被动暴露和间歇性低氧化症的数据有限.
研究的目的:
- 为了研究急性被动间歇性和持续性低氧化症对食欲的厌食性影响.
- 在不同的低血压条件下 (模拟高海拔与OSA) 和营养状态 (禁食与食后) 中比较食欲反应.
主要方法:
- 来自四项随机交叉试验的数据汇总,涉及健康成年人和患有OSA的个人.
- 使用模拟高空 (FiO2=0.12) 和中度OSA (15周期/小时,85%的SpO2).
- 胃口在6小时内被评估为正常性,间歇性和连续性低氧症在禁食和食后状态下.
主要成果:
- 急性间歇性低氧症在食后状态中导致了统计学上显著的,但不是临床上显著的食欲减少.
- 低氧症的厌食效应在不同的方法和营养状态之间是不一致的.
- 个人因素影响了normoxia和hypoxemia期间的食欲反应.
结论:
- 急性被动性低氧血症对食欲的影响是异质的.
- 低氧症期间的食欲调节因诱发低氧症的方法和个体的营养状况而异.
- 需要进一步的研究,以了解影响低氧症期间食欲的因素的复杂相互作用.
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