生产性甲状腺功能低下症和青少年的学业成绩:一个基于人口的兄弟姐妹控制研究
Anna Gunnerbeck1, Cecilia Lundholm2, Ulrika von Döbeln3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children's Hospital, Neuropediatric Unit, Karolinska University Hospital, Stockholm, Sweden.
The Journal of pediatrics
|August 16, 2024
概括
患有先天性甲状腺功能低下症 (CH) 的儿童的学业成绩略低. 那些在正常新生儿查后被诊断晚的人学业成绩最低,影响了数学技能.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 发育儿科 发育儿科
- 公共卫生查 公共卫生查
背景情况:
- 先天性甲状腺功能低下症 (CH) 是一种需要早期干预的疾病.
- 新生儿查旨在在出生时检测CH.
- 了解CH的长期学术成果对于支持至关重要.
研究的目的:
- 评估CH的9年级学生的学业成绩.
- 通过新生儿查检测到的CH和后来诊断到的CH之间的结果进行比较.
- 分析CH对学业成绩的影响,考虑家庭因素.
主要方法:
- 使用瑞典登记册 (1982-1997) 对超过150万儿童进行全国性研究.
- 定义的CH组:异常查 (DBS+/LT4+) 和正常查,但后来诊断 (DBS-/ICD+/LT4+).
- 通过分数和国家测试评估学校成绩;兄弟姐妹分析控制遗传/环境因素.
主要成果:
- 与对照组相比,CH儿童的分数总和较低.
- CH与较差的国家测试结果有关,特别是在数学方面.
- 在正常新生儿查后诊断出CH的儿童中,学业成绩最低.
结论:
- 先天性甲状腺功能低下症与学校成绩略有下降有关.
- 迟迟诊断CH,即使在正常的初始查,也与较差的学业成果有关.
- 早期发现和管理CH对于优化教育成就至关重要.
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