在对前额皮质进行跨直流刺激后,血中白蛋白-6度降低
Beyza N Aydin1, Emma J Stinson1, Katherine T Travis1
1Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ, United States.
Behavioural brain research
|August 16, 2024
概括
在肥胖的成年人中,向左脊侧前额叶皮层 (L-DLPFC) 进行阳道跨直接刺激 (tDCS) 降低了互白素-6 (IL-6) 度. 这一发现表明,通过调节炎症标志物,tDCS可能为体重管理提供治疗效益.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 肥胖问题研究研究
背景情况:
- 众所周知,针对背侧前额皮层 (DLPFC) 的跨直接刺激 (tDCS) 可以减少食物摄入量和饥饿感.
- 然而,它对循环中的益/抗炎和食欲激素的影响在很大程度上仍未得到研究.
研究的目的:
- 评估左侧DLPFC (L-DLPFC) 的重复阳极tDCS对关键激素度的影响.
- 探索tDCS在管理与肥胖相关因素中的潜在治疗机制.
主要方法:
- 29名肥胖的成年人每天连续三次接受了针对L-DLPFC的阳道或虚拟tDCS.
- 在干预期之前和之后测量了IL-6,素,皮质醇,TNF-α,IL-1β,格林,PYY和GLP-1的禁食血度.
主要成果:
- 与假药相比,阳道tDCS显著降低了IL-6度,独立于热量摄入量.
- 在其他测量激素 (素,皮质醇,TNF-α,IL-1β, ghrelin,PYY,GLP-1) 中没有发现显著变化.
- 较高的热量摄入与IL-1β和格林的增加有关,但这并没有受到tDCS干预的影响.
结论:
- 对L-DLPFC的阳极tDCS有效降低了IL-6度,这是与脂肪和饮食行为相关的炎症标志物.
- 这些发现表明tDCS在通过调节炎症通路来控制肥胖方面可能发挥治疗作用.
- 需要进一步的研究来阐明tDCS对荷尔蒙调节和体重管理的全部影响.
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