基于免疫的机器学习预测精神分裂症和双极性障碍的诊断和疾病状态
Katrien Skorobogatov1, Livia De Picker1, Ching-Lien Wu2
1Scientific Initiative for Neuropsychiatric and Psychopharmacological Studies (SINAPS), University Psychiatric Hospital Campus Duffel (UPCD), Rooienberg 19, 2570 Duffel, Belgium; Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Campus Drie Eiken, S.003, Universiteitsplein 1, 2610 Wilrijk, Belgium.
Brain, behavior, and immunity
|August 16, 2024
概括
机器学习模型能够准确地区分精神分裂症和双相情感障碍与使用IL-6和TNF-ɑ等免疫标记物的对照. 由于共享的免疫路径,区分精神分裂症和双相情感障碍仍然具有挑战性.
科学领域:
- 神经科学和免疫学 神经科学和免疫学
- 计算精神病学是一种计算精神病学.
- 生物标志物发现发现
背景情况:
- 精神分裂症和双相情感障碍的诊断往往会延迟,导致错过或不正确的早期诊断.
- 这两种疾病都与免疫系统异常有关.
- 机器学习显示出诊断生物标志物的前景,但免疫标志物未得到充分利用.
研究的目的:
- 开发监督机器学习模型,用于预测精神分裂症和双相情感障碍的诊断和疾病状态.
- 为了利用一个面板的外围 kynurenine 代谢产物和细胞因子作为预测生物标志物.
主要方法:
- 利用横截面I-GIVE队列,包括急性/稳定精神分裂症,急性/稳定双相情感障碍患者和健康对照.
- 量化血清基努瑞宁代谢物和细胞因子 (IL-6,TNF-ɑ,IFN-γ等) 的数量. 使用LC-MS/MS和V-plex测定方法.
- 执行监督机器学习与嵌套交叉验证和分割集灵敏度分析.
主要成果:
- 模型实现了很好的准确性 (AUC 0.804),将患者与对照区分开来,具有很高的积极预测值.
- 精神分裂症和双相情感障碍是与对照组单独分离的 (SCZ AUC 0.824; BD AUC 0.802).
- 增加IL-6,TNF-ɑ,PICO和减少IFN-γ,QUINO预测了患者分类;区分急性与稳定状态产生了公平的AUC (0.713);区分SCZ与BD产生了糟糕的AUC (0.627).
结论:
- 基于免疫的测量,特别是IL-6,TNF-ɑ,IFN-γ,QUINO和PICO,显示出在精神分裂症和双相情感障碍中预测分类模型的潜力.
- 机器学习有效地将患者与对照区分开来,但难以区分精神分裂症和双相情感障碍,这表明共享免疫路径.
- 未来的研究需要更大的,多中心研究和多域模型进行临床翻译.
相关概念视频
Biological Causes of Schizophrenia
51
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
51
Bipolar Disorder
60
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
60
Schizophrenia
72
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
72
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
529
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
529
Mania and Antimanic Drugs: Overview
155
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
155
Diagnostic and Statistical Manual of Mental Disorders (DSM)
50
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
50


