武力健康保护的毒性参考值:临时职业暴露指南
Lisa M Sweeney1, Teresa R Sterner2
1UES, Inc., 4401 Dayton Xenia Road, Dayton, OH, 45432, USA.
Regulatory toxicology and pharmacology : RTP
|August 16, 2024
概括
部队健康保护计划面临挑战,因为对战斗人员化学物质暴露的毒性参考值 (TRV) 存在知识差距. 这项研究使用多种方法推导了临时的TRV,使得在职业安全方面能够更好地基于风险的决策.
科学领域:
- 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
- 风险评估 风险评估
背景情况:
- 部队健康保护计划旨在保持战斗人员的准备状态.
- 有毒性参考值 (TRV) 的现有知识缺口阻碍了对化学物质暴露的风险评估.
- 数百种感兴趣的化学物质有未定义的TRV.
研究的目的:
- 为缺乏既定值的物质推导临时的TRV.
- 解决知识差距,限制基于风险的职业风险决策.
- 评估各种估计职业TRV的方法.
主要方法:
- 使用国际数据库生成候选TRV,化学相似性 (最近邻居),持续时间调整,定量活动关系和毒理关注的门.
- 根据证据权重的方法选择了临时的TRV,优先考虑动物生物测试衍生的衍生无效水平 (DNELs),如有.
- 在TRV估计中采用了新的近邻方法,经验调整和职业暴露范围.
主要成果:
- 为84种化合物产生候选TRV,占有18%的感兴趣物质.
- 只有19个DNEL可用,需要依赖其他估计方法.
- 最接近邻近的方法,经验调整和职业暴露频段被证明是有效的,以合理的信心来估计TRV.
结论:
- 可以使用多种方法结合得出临时的TRV来填补关键的知识空白.
- 考虑方法质量和一致性的证据权重对于选择可靠的TRV至关重要.
- 这些衍生的TRV支持对战斗人员职业健康和安全的基于风险的决策进行改进.
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