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囊氨酸玛酶缺乏症在小鼠中夸大了二甲基尼托拉胺诱导的肝损伤

Samantha Ligi1, Arm Ali1, Guangdong Yang1

  • 1School of Natural Sciences, Laurentian University, Sudbury, Canada; Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Canada.

Nitric oxide : biology and chemistry
|August 16, 2024
PubMed
概括

囊氨酸马酶 (CSE) 缺乏会使小鼠的肝损伤和纤维化恶化. 向CSE/硫化 (H2S) 途径可能为肝脏疾病提供新的治疗方法.

关键词:
赛斯氨酸玛-酶是什么甲基氨酸二甲基氨酸.H (((2) S S 的情况.肝脏损伤 肝脏损伤

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
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