结核病在中国高负担地区的传播动态:使用全基因组测序进行了为期8年的基于人口的研究
Wencong He1, Yunhong Tan2, Zexuan Song3
1Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
概括
湖南的结核病 (TB) 传播主要发生在县内. 关键的风险因素包括男性性别,30-60岁,少数民族,非农民和耐药结核病,指导有针对性的预防策略.
科学领域:
- 基因组流行病学基因组流行病学
- 公共卫生 公共卫生
- 传染病的传播是传染病的传播.
背景情况:
- 结核病 (TB) 仍然是全球和中国的重大公共卫生挑战.
- 了解本地传播动态对于有效的控制策略至关重要.
研究的目的:
- 在湖南省调查结核病传播模式,并确定相关的风险因素.
- 为制定有针对性的结核病预防和控制战略提供信息.
主要方法:
- 进行了为期8年的以人口为基础的基因组流行病学研究.
- 通过使用12个单核酸多态度值来定义基因组集群.
- 使用后勤回归分析了风险因素,并通过内核密度分析确定了热点.
主要成果:
- 确定了275个TB集群 (24.7%的集群率),其中大多数菌株来自同一县.
- 在8.4%的集群中发现药物耐药性概况的差异,其中诺抗性是最常见的.
- 确定男性性别,30-60岁,少数民族,非农民,退行结核病患者和MDR/RR-TB感染作为传播的独立风险因素.
结论:
- 湖南最近的结核病传播在很大程度上发生在县内.
- 确定的风险因素和传播热点为有针对性的结核病预防和控制提供了科学基础.
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