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Updated: Jun 16, 2025

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
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A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes

Published on: November 7, 2012

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通过平行轨迹在酶的进化中出现的机械形状和基质选择性概况

Christos S Karamitros1,2, Kyle Murray3,4, Yoichi Kumada5

  • 1Department of Chemical Engineering, University of Texas at Austin (UT Austin), Austin, TX, USA.

Nature communications
|August 16, 2024
PubMed
概括

实验室进化创造了不同的人类 kynureninase (HsKYNase) 酶. 尽管活动相似,但它们表现出不同的结构动力学和机制,揭示了对酶进化的洞察力和通用主义者与专业主义者的特征.

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