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Updated: Jun 16, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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铜催化高度可切换的1-三甲基 (trifluoromethyl) 基因的脱化和化

Jun Xu1,2, Zhao-Cheng Yan1,2, Li Liu1,2

  • 1School of Food and Biological Engineering, Hefei University of Technology, Hefei, China.

Nature communications
|August 16, 2024
PubMed
概括

研究人员开发了一种通用的铜催化方法,从三甲基化基中合成各种含CF2的化合物. 这种方法可以实现选择性脱和化,这对于药物发现和材料科学至关重要.

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
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