在COVID-19幸存者中,体育训练对凝血参数,白内素-6和血管素转化酶-2的影响
Soheila Binabaji1, Mohammad Rahimi1, Hamid Rajabi2
1Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran.
Scientific reports
|August 16, 2024
概括
体育训练改善了COVID-19幸存者的肌肉耐力和有氧能力. 虽然在统计学上并不显著,但运动对炎症标志物,凝血和康复期间的生活质量有潜在的益处.
科学领域:
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
- 心血管健康的心血管健康
背景情况:
- COVID-19 影响免疫和凝血系统,增加炎症和凝血风险.
- ангиотензин转化酶2 (ACE2) 是SARS-CoV-2进入的关键受体.
- 由于这些系统性影响,COVID-19后的并发症可能会出现.
研究的目的:
- 为了研究一个为期8周的体育训练计划对COVID-19康复患者的炎症,凝血和身体因素的影响.
- 评估运动对介质素-6 (IL-6),ACE2,纤维素和D-二次体水平的影响.
- 评估有氧能力,肌肉耐力,生活质量和睡眠的变化.
主要方法:
- 一项随机对照试验与27名参与者 (20-45岁) 最近从COVID-19中恢复过来.
- 参与者被分配到一个培训组 (n=14) 或一个控制组 (n=13).
- 干预持续了8周,在基线,第4周和第8周测量IL-6,ACE2,纤维素,D-二次体,有氧能力和肌肉耐力.
主要成果:
- 与对照组相比,训练组的肌肉耐力 (p=0.004) 和有氧能力 (p=0.009) 显著改善.
- 在训练组中,IL-6和纤维素的血清水平呈现下降趋势,尽管在统计学上并不显著 (p>0.05).
- 在ACE2,D-二次体,生活质量或睡眠方面没有发现群体之间的统计学上显著差异.
结论:
- 身体训练似乎对凝血系统和COVID-19恢复中的炎症因素有有益影响.
- 运动可以通过积极影响身体能力和潜在的系统标记物来促进恢复.
- 需要对更大的样本进行进一步的研究,以确认这些观察到的好处的统计学意义.
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