新型系统性免疫-炎症指数和经典血液学参数在预测抑郁症,自杀企图和治疗反应中的相对值
Putrada Ninla-Aesong1,2, Pongtorn Kietdumrongwong3, Sudan Prasad Neupane4
1Department of Medical Science, School of Medicine, Walailak University, Nakhon Si Thammarat, Thailand. putrada.ni@mail.wu.ac.th.
Scientific reports
|August 16, 2024
概括
像SII和SIRI这样的新型炎症标志物,以及像NLR这样的传统标志物,在识别主要抑郁症 (MDD) 和预测自杀企图和SSRI治疗反应方面表现出前景.
科学领域:
- 血液学 血液学 血液学
- 精神病学是一个精神病学.
- 炎症标志物的炎症标志物
背景情况:
- 重度抑郁症 (MDD) 的诊断和治疗反应可能具有挑战性.
- 新的炎症标志物,如系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI),可能会提供新的见解.
研究的目的:
- 为了比较新型 (SII,SIRI) 和经典 (NLR,MLR,PLR,血小板计数) 血液学指数的疗效.
- 要区分MDD患者与没有自杀企图 (SA).
- 为了确定非对选择性血清素再吸收抑制剂 (SSRI) 治疗反应的预测因素.
主要方法:
- 包括139名年轻成人MDD患者和54名健康对照 (HC).
- 分析了基线血液学指数,包括NLR,MLR,PLR,血小板计数,SII和SIRI.
- 使用的接收器操作特征 (ROC) 曲线分析以评估诊断功率.
主要成果:
- 与HC相比,NLR和SII在MDD患者中升高,AUC> 0.7.7.
- 患有SA的MDD患者表现出更高的MLR和SIRI,并趋向于增加NLR.
- 在区分SA方面,NLR表现优于其他指数,在区分SA方面表现优越.
- 与响应者相比,对SSRI治疗没有反应的患者的血小板数和PLR (AUC > 0.7) 增加.
结论:
- 血液学指数,无论是新的还是古典的,都显示出预测抑郁症,自杀企图和SSRI治疗结果的潜力.
- 结合各种血液学标记可能会提高MDD及其临床过程的预测准确性.
关键词:
抑郁症的结果 抑郁症的结果中性粒细胞与淋巴细胞的比率 (NLR)血小板计数 血小板计数 血小板计数 血小板计数血小板与淋巴细胞的比率 (PLR)系统性免疫-炎症指数 (SII)系统性炎症反应指数 (SIRI)更多相关视频
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
69
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
69
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:27Depressive Disorders: Etiology
59
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
59
01:27Psychoneuroimmunology: Cardiovascular Disease
28
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
28