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通过光学连贯性断层扫描扫描血管学评估的莱维体痴呆症中神经网膜和微血管网膜特征

Giuseppe Maria Albanese¹, Magda Gharbiya¹, Giacomo Visioli²

¹Department of Sense Organs, Sapienza University of Rome, 155, Viale del Policlinico, Rome, 00161, Italy.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|August 16, 2024

概括

视网膜毛细血管的变化,特别是周毛细血管密度 (ppVD) 的降低,与患有勒维体痴呆症 (DLB) 有关. 这些发现表明了诊断DLB和监测疾病进展的潜在生物标志物.

科学领域:

眼科医生眼科眼科
神经学神经学
医疗成像医学成像

背景情况:

勒维体痴呆症 (DLB) 是一种进展性神经退行性疾病.
目前对DLB的诊断方法可能具有侵入性或缺乏特异性.
确定可靠的生物标志物用于早期DLB诊断和监测至关重要.

研究的目的:

用先进的成像技术研究DLB患者的视网膜微血管和结构变化.
确定这些视网膜变化是否可以作为DLB的潜在生物标志物.

主要方法:

一项涉及15名DLB患者和18名健康对照者的横截面研究.
使用光谱域光学一致性断层扫描 (SD-OCT) 和光学一致性断层扫描血管扫描 (OCTA) 进行视网膜成像.
采用后勤回归分析来确定DLB的重要预测因素.

主要成果:

与对照组相比,DLB患者表现出显著降低的表面和深黄斑血管密度 (SVD和DVD) 和周周血管密度 (ppVD) (p <0.01).
在DLB中,SD-OCT揭示了中央黄斑厚度的降低 (CMT,p < 0.001) 和状细胞层-内状层 (GCL-IPL) 稀薄 (p < 0.01).
减少的ppVD成为DLB的重要预测因素 (p = 0.030).

结论:

视网膜毛细管损伤,特别是减少的ppVD,可能反映在DLB中大脑低 perfusion.
这些变化可能与血管内皮生长因子 (VEGF) 和α-synuclein水平的改变有关.
需要进一步的研究来验证用于DLB诊断和进展监测的视网膜生物标志物.

关键词:

患有勒维体的痴呆症 (DLB)神经退行性疾病的神经退行性疾病光学一致性断层扫描血管图 (OCTA)周周血管的密度 (ppVD)视网膜生物标志物视网膜生物标志物视网膜神经纤维层 (RNFL) 是一种神经纤维层.视网膜变化视网膜变化血管内皮生长因子 (VEGF)

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