在急性缺血性中风患者的压力高血糖比率和功能结果之间存在关联
Shiyan Xiao1, Maofeng Gao2, Shudi Hu2
1Department of Gastroenterology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
BMC neurology
|August 16, 2024
概括
从禁食血糖和血红蛋白A1c计算的压力高血糖比率 (SHR) 与急性缺血性中风 (AIS) 患者的较差结果有关. 较高的SHR水平与90天后功能恢复不良的可能性更大.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 临床医学 临床医学
背景情况:
- 急性缺血性中风 (AIS) 是导致残疾的主要原因.
- 在AIS患者的功能性结果的有效预测对于治疗规划至关重要.
- 应激高血糖在AIS预后中的作用需要进一步阐明.
研究的目的:
- 评估压力高血糖比率 (SHR) 与AIS后90天的功能表现不佳之间的关联.
- 确定SHR是否可以作为AIS患者功能恢复的预测标记.
主要方法:
- 对1255名AIS患者的回顾性分析,可获得禁食血糖 (FBG) 和血红蛋白A1c (HbA1C) 数据.
- SHR计算为FBG/HbA1C,并分析在三角动物中.
- 用修改的兰金尺度 (mRS) 评分为2-6的90天定义的功能性不良结果.
- 统计分析包括单变量,多重回归,分层和交互式分析.
主要成果:
- 与最低三位数 (调整后OR = 2.84,P < 0.0001) 相比,SHR三位数最高的患者表现出功能性结果差的几率明显较低.
- 这种关联在调整多个临床共变量后仍然显著,包括白细胞计数,葡萄糖水平和中风严重程度.
- 压力高血糖率 (SHR) 与AIS患者的功能结果有显著的关联.
结论:
- 由FBG/HbA1C衍生出的压力高血糖比率 (SHR) 与急性缺血性中风 (AIS) 患者在90天后功能表现不佳的可能性增加有关.
- 在AIS管理中,SHR可以作为一个有价值的预后指标.
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