大脑-小脑皮层活动和连接性是宫性 dystonia 中潜在的感官技巧
Nai-Qing Cai1,2,3, Wu-Xiang Shi4,5, Ru-Kai Chen1,2,3
1Department of Neurology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Annals of clinical and translational neurology
|August 17, 2024
概括
宫性 dystonia (CD) 中的感觉技巧 (ST) 改变了大脑活动,减少了感觉和小脑区域的马功率. 在ST期间,在CD患者中观察到增强的感觉运动网络连接,特别是涉及小脑.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 生物医学工程 生物医学工程
背景情况:
- 宫性 dystonia (CD) 是一种运动障碍,其特点是不自发的部肌肉收缩.
- 感官技巧 (ST) 是可以暂时缓解某些CD患者运动症状的操作.
- 在CD中ST效应的潜在神经机制仍然不完全理解.
研究的目的:
- 在CD患者的ST期间调查脑电图 (EEG) 活动和大脑和小脑皮层的功能连接.
- 为了区分ST的神经相关物与CD中的运动执行.
- 探索小脑在调解ST效应中的作用.
主要方法:
- 从15名CD患者和15名健康对照者 (HCs) 获得了同时进行的EEG和电肌图 (EMG) 记录.
- 进行了EEG源分析和功能连接性分析.
- 计算了光谱密度的相对功率变化,以评估感官处理效应.
主要成果:
- 在CD患者中,ST执行导致CD患者初级感觉和小脑皮层的低玛 (30-50 Hz) 光谱功率下降.
- 与HC相比,在ST维护阶段,马功率的这种减少在ST维护阶段持续存在.
- 患有CD的患者在感觉运动网络中表现出强化的功能连接,特别是在感觉和小脑区域之间.
结论:
- 在CD中的ST改变皮质刺激性和功能连接性,由玛振荡调节.
- 这些发现表明,ST效应不仅仅涉及运动部件.
- 小脑似乎在介导ST在宫 dystonia的治疗效果中发挥着重要作用.
相关概念视频
Major Somatic Sensory Pathways
929
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
929
Indirect Motor Pathways
1.5K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.5K
Cerebellum: Anatomical Regions
1.5K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
1.5K
Diencephalon: Thalamus and Information Relay
1.5K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.5K
Brainstem
1.9K
The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...
1.9K
Cranial Nerves: Types Part II
2.0K
Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
2.0K


