基于化学抗原受体T细胞的癌症细胞疗法:一个介绍和印度的观点
Reena J Rathod1, Reghu K Sukumaran2, Neelam Kedia1
1Cell and Gene Therapy Division, Intas Pharmaceuticals, Ahmedabad, Gujarat, India.
Indian journal of cancer
|August 17, 2024
概括
卡特疗法为癌症患者提供了新的希望,但高成本和后勤问题限制了获取,特别是在印度. 本综述探讨了T细胞免疫疗法,重点关注CAR-T.
科学领域:
- 癌症生物学和治疗方法
- 细胞免疫疗法细胞免疫疗法
- 收养细胞的转移
背景情况:
- 癌症治疗正在积极研究患者自身免疫系统的使用.
- 收养细胞转移,包括CAR-T疗法,代表了免疫治疗的重大进步.
- 卡特-T疗法在复发性/耐药性癌症方面表现有前途,但面临着可访问性挑战.
研究的目的:
- 审查T细胞免疫疗法,特别关注CAR-T疗法.
- 分析印度背景下CAR-T治疗的现状和未来前景.
- 讨论CAR-T疗法的科学,制造,临床和商业方面.
主要方法:
- 关于T细胞免疫疗法和CAR-T疗法的文献综述.
- 分析科学,制造,临床和商业因素.
- 专注于印度医疗保健领域的具体挑战和机会.
主要成果:
- 在癌症治疗中,CAR-T疗法开辟了新的范式.
- 包括高成本,物流和经济因素在内的重大障碍限制了其影响力,特别是在印度.
- 该审查提供了CAR-T疗法的全球和印度场景的全面概述.
结论:
- 卡特疗法具有巨大的潜力,但需要解决成本和可访问性问题.
- 进一步的研究和开发对于更广泛的实施至关重要,特别是在像印度这样的资源有限的环境中.
- 该审查强调了为将CAR-T疗法推向印度患者提供量身定制策略的必要性.
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