在大麻使用期间THC,CBD,社会背景和主观影响之间的事件级协会
Yi-Chun Chang1, Renee E Magnan1, Michael J Cleveland2
1Department of Psychology, Washington State University Vancouver, Vancouver, WA, USA.
Journal of psychopharmacology (Oxford, England)
|August 17, 2024
概括
较高的Δ9-四大麻 (THC) 剂量和社交大麻使用增加了高兴和喜欢的感觉. 大麻二醇 (CBD) 也增强了喜欢,而社会背景调节了THC对主观体验的影响.
科学领域:
- 心理学 心理学 心理学
- 药理学 药理学是指药理学的学科.
- 大麻科学 大麻科学
背景情况:
- 有限的研究探讨了大麻产品的功效和社会背景如何影响现实世界的主观影响.
- 了解这些因素对于公共卫生和减少危害策略至关重要.
研究的目的:
- 调查 Δ9-四大麻 (THC) 和大麻 (CBD) 剂量,以及社会背景对急性大麻使用的主观影响的影响.
- 检查THC,CBD,社会环境和真实世界大麻消费用户体验之间的相互作用.
主要方法:
- 一个为期14天的生态瞬间评估 (EMA) 协议,涉及96名常规大麻使用者.
- 参与者完成了关于大麻产品细节 (THC/CBD强度和数量),社会背景和每次使用后的主观经验的调查.
- 基线评估捕获了人口统计和大麻使用模式.
主要成果:
- 与平均使用相比,较高的THC剂量与增加的高兴感和更大的喜欢感有显著的关联.
- 喜欢的增加也与较高的CBD剂量和社会使用环境有关.
- 一个显著的相互作用表明,单独使用缓和了THC剂量和不喜欢之间的关系,而社交使用没有.
结论:
- 社会背景显著影响大麻使用的主观体验,与THC剂量相互作用.
- 与大麻相关问题水平较高的个体报告说,不管他们感觉高吗,他们更少喜欢和更不喜欢大麻.
- 调查结果表明,针对有问题的大麻使用的干预措施应该解决用户的期望和动机,考虑在社交环境和孤独环境中的不同主观经验.
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