同时检测尿液中的生物标志物使用多校准电位计传感阵列与便携式分析仪相结合
Shengqi Cheng1, Fan Wang2, Shaohua Zuo3
1School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, People's Republic of China.
Analytical chemistry
|August 17, 2024
概括
一个新的10通道电位计传感阵列使得可以同时检测尿液中的尿酸,肌素和尿素. 该设备提供准确的实时健康监测,用于早期发现疾病.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 传感器技术 传感器技术
背景情况:
- 尿酸 (UA),尿中的肌素和尿素是诊断脏疾病的关键生物标志物.
- 家庭健康监测设备对于定期和实时跟踪健康状况至关重要.
- 精确且同时检测多个尿液生物标志物对于有效的疾病管理至关重要.
研究的目的:
- 开发一个多分析器传感阵列,同时检测尿液中的UA,肌素,尿素和pH.
- 整合校准通道和温度/pH补偿,以提高监测准确度.
- 为了验证开发系统的性能与商业诊断工具进行实践应用.
主要方法:
- 制造一个10通道电位计传感阵列,具有特定的电极组,用于UA,肌素,尿素和pH.
- 使用功能化的传感材料,包括Pt/碳纳米管 (CNTs) -尿酶,肌氨酸减小酶,Au@urease和聚氨酸.
- 整合校准通道和外部探头以进行pH和温度补偿.
- 开发一种便携式电位计分析仪,用于数据处理和直接显示结果.
主要成果:
- 传感阵列表现出高灵敏度和选择性,可同时检测UA,肌素,尿素和pH.
- 综合校准和补偿方法显著提高了国内监测的准确性.
- 开发的系统与商业套件和pH计的结果有很好的一致性.
- 在实践模式下,分析仪成功显示了目标分析物和pH的直接度值.
结论:
- 拟议的电位计传感阵列非常适合开发先进的家庭健康监测设备.
- 该系统提供了一种可靠和准确的方法,用于同时进行尿液生物标志物分析,以促进早期疾病检测.
- 这项技术具有显著的潜力,可以改善患者的自我管理和医疗保健的可访问性.
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