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A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
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相关实验视频

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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哪些因素影响细胞病理学家对病例报告的信心?

Harriet Evans1,2, Peter K Kimani3, Louise Hiller3

  • 1Histopathology Department, University Hospitals Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry, CV2 2DX, UK. harriet.evans4@nhs.net.

Virchows Archiv : an international journal of pathology
|August 17, 2024
PubMed
概括

病理学家的诊断信心有所不同,受病例复杂性和诊断协议的影响,而不是经验. 虽然数字病理学显示信心略有下降,但病理学家仍然有信心使用它进行诊断.

关键词:
乳腺病理学 乳腺病理学诊断的信心 诊断的信心数字病理学数字病理学胃肠道病理 胃肠道病理脏病理学 脏病理学皮肤病理学 皮肤病理学

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科学领域:

  • 组织病理学 组织病理学
  • 数字病理学数字病理学
  • 医学诊断 医学诊断 医学诊断

背景情况:

  • 组织病理学是一种解释学科,病理学家的诊断信心各不相同.
  • 量化诊断信心及其影响组织病理学因素的研究不足.

研究的目的:

  • 量化病理学家在多个变量和专业的诊断信心.
  • 识别影响对组织病理学诊断信心的因素,比较光显微镜 (LM) 和数字病理学 (DP).

主要方法:

  • 来自六个NHS信托的16位病理学家分析了四个专业的16187个诊断.
  • 每个病理学家都报告了每个病例两次:一次在LM上,一次在DP上.
  • 病理学家记录了诊断信心,使用7点的利克特等级对每个诊断.

主要成果:

  • 所有调查的变量都显著预测了诊断信心,除了病理学家的经验.
  • 较低的信心与困难病例,诊断变化 (病理学家间和病理学家内) 和错误诊断有关.
  • 对于LM (率比1.09) 和DP,观察到名义上更高的信心,尽管病理学家对DP报告表示信心.

结论:

  • 对组织病理学的诊断信心受到病例难度,诊断一致性和准确性的影响,而不是经验.
  • 外部质量控制和同行评审对于提高报告准确性和信心是有价值的.
  • 虽然LM显示的信心略高,但DP是用于基因病学诊断的可靠工具.