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Updated: Jun 16, 2025

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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一般准平衡多价值结合模型用于研究生物药物的多样化和复杂的药物受体相互作用

Chee M Ng1, Robert J Bauer2

  • 1NewGround Pharmaceutical Consulting LLC, Foster City, CA, USA. cheemng@newgroundpc.com.

Journal of pharmacokinetics and pharmacodynamics
|August 17, 2024
PubMed
概括

这项研究引入了一个新的建模框架,使用微分代数方程 (DAE) 来分析各种生物药物的复杂药物受体结合动力学,包括双特异性抗体 (BsAb) 和工程IgG变体. 开发的准平衡多价值药物受体结合 (QEMB) 模型增强了对生物行为的理解.

关键词:
生物制剂 生物制剂 生物制剂微分代数方程 微分代数方程多价值结合剂的结合物药理动力学是什么 药理动力学药理动力学 药理动力学准平衡约束模型的约束模型

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