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鉴定和功能分析新型低血糖和抗氧化从豆

Pei Li^1,2, Guoping Chen¹, Rongyao Liang¹

¹School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, Guangdong Province, China.

Plant foods for human nutrition (Dordrecht, Netherlands)

|August 17, 2024

概括

小生物活性 (CBP) 通过抑制α-葡萄糖酶 (GAA) 和增强葡萄糖代谢,表现出低血糖作用. 这些天然素还可以提高胰岛素抵抗细胞的抗氧化能力,为功能性食物提供潜力.

科学领域:

营养生物化学营养生物化学
分子营养分子营养学
食品科学食品科学食品科学

背景情况:

豆蛋白具有已证明的低血糖作用.
具体的生物活性化合物和机制在很大程度上仍然未被描述.
胰岛素抵抗 (IR) 和相关的代谢功能障碍需要新的治疗策略.

研究的目的:

隔离和描述具有低血糖活性的小生物活性 (CBP).
阐明CBP对α-葡萄糖酶 (GAA) 和抗胰岛素细胞的作用机制.
识别CBP中的新生物活性及其潜在的分子标.

主要方法:

酵素水解和凝透色谱用于CBP提取.
在胰岛素抵抗性HepG2细胞中进行GAA抑制和细胞活性的体外试验.
用于标识和分子对接进行目标分析的LC-MS/MS.

主要成果:

CBP-75-3 抑制了GAA活性,并改善了IR细胞活力.
在IR-HepG2细胞中,CBP-75-3增强了葡萄糖消耗和糖原合成.
鉴定了29种新的生物活性,通过结与GAA活性位相互作用,这表明了低血糖机制.

结论:

来自豆蛋白 (CBP) 的新生物活性具有显著的低血糖和抗氧化特性.
CBP-75-3显示出作为功能性食品的天然成分的潜力,其向的是代谢健康.
这项研究为开发豆衍生的基础,用于管理高血糖和胰岛素抵抗.

关键词:

抗氧化能力的抗氧化能力.豆是什么意思豆是什么意思低血糖性酸是一种低血糖性酸.胰岛素耐药性胰岛素耐药性是一种分子对接是分子对接.

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