一个干细胞激活状态,将精子生成与Drosophila雄性动物的社会相互作用结合起来
Javier Martin-Diaz1, Salvador C Herrera1
1Andalusian Center for Developmental Biology (CABD), CSIC, UPO, Junta de Andalucía, Carretera de Utrera km 1, 41013 Sevilla, Spain.
Cell reports
|August 17, 2024
概括
男性果通过费洛蒙感知潜在伴侣时增加精子生产. 这触发了涉及肌肉和神经细胞的信号通路,促进了生殖成功的胚胎干细胞增殖.
科学领域:
- 生殖生物学 生殖生物学
- 动物行为 动物行为
- 发育生物学是发展生物学.
背景情况:
- 成功繁殖需要在社会线索,生理学和雌雄体生产之间进行协调.
- 虽然在女性身上进行了广泛的研究,但对社会线索的感知及其对男性生理学和生殖生成的影响不太了解.
- 果 (Drosophila) 作为研究男性生殖调节的模型.
研究的目的:
- 研究社会线索如何影响雄性生殖生理学和Drosophila中的精子生成.
- 为了识别参与雄性性体生产的信号通路,以应对潜在的交配伙伴.
主要方法:
- 使用Drosophila melanogaster作为一个模型生物.
- 研究了潜在交配伙伴可用性对丸干细胞种群的影响.
- 分析了费罗蒙的沟通通路.
- 确定了关键的信号分子和途径,包括瘤亡因子α (TNF-α) /Eiger,八胺,Jun N-终端激酶 (JNK) 途径和动态.
主要成果:
- 潜在的交配伙伴的可用性激活了多索菲拉雄性丸干细胞种群,增强了精子生成.
- 这种激活是通过激素通信发生的,独立于实际交配或雌性相互作用.
- 确定了一种涉及肌肉分泌的TNF-α/Eiger和神经元分泌的八胺的信号网络.
- 这些信号激活JNK通路,改变囊干细胞中的动态,导致生殖系干细胞的增多.
结论:
- 果虫雄性通过激素感知社会线索,这些激素刺激精子生成.
- 器官间的沟通,包括肌肉和神经元的信号传递,调节男性生殖系干细胞的增殖.
- 这项研究揭示了男性社会暗示介导的生殖调节的新机制.
相关概念视频
The Ratio of X Chromosome to Autosomes
8.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.5K
Spermatogenesis
102.3K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.3K
Yeast Signaling
14.5K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
14.5K
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Dosage Compensation
6.1K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.1K


