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皮质有机体支持常存记忆CD8 T细胞分化

Max R Ulibarri1, Ying Lin2, Julian C Ramprashad1

  • 1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

Cell reports
|August 17, 2024
PubMed
概括

研究人员开发了一种新方法,在实验室环境中培养常驻记忆T细胞 (TRMs). 这种可扩展的有机体系统允许对TRM功能和抗病毒免疫力进行高通量研究.

关键词:
CD8 寄居记忆T 细胞CP: 发育生物学CP: 免疫学 免疫学一个T细胞和一个上皮细胞的交叉连接.抗病毒的CD8 T细胞细胞.在体外分化的 in vitro差异化.记忆T细胞分化粘膜免疫反应的免疫反应有机体建模器官模型阴道上皮质有机体

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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