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通过现代病变-症状映射的镜头对角性环损伤后的症状学
1Department of Biomedical Engineering and Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates; Healthcare Engineering Innovation Center (HEIC), Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
概括
角性 (AG) 的损伤会引起各种症状,使大脑与行为之间的关系变得复杂. 现代的病变-症状映射对于理解AG综合征及其潜在的神经系统至关重要.
科学领域:
- 神经科学是一个神经科学.
- 认知神经学 认知神经学
- 神经心理学 神经心理学
背景情况:
- 大脑与行为之间的关系是复杂的,对特定区域的损伤,如角 (AG),导致多样化,有时是不可预测的缺陷.
- 与AG损伤相关的症状包括左右混,手指无知症,注意力缺陷,词汇表达障碍以及句子处理,记忆,数字处理和手势模仿障碍.
- 这些症状有时被归类为AG综合征或格斯特曼综合征,但精确的神经支仍然不清楚.
研究的目的:
- 通过使用现代的病变-症状映射框架,回顾和解释角性 (AG) 损伤后的复杂症状.
- 突出关键的挑战和未来的研究方向,以全面了解AG综合征.
- 为了弥合损伤数据和功能神经成像在特征AG功能之间的差距.
主要方法:
- 应用最近的大脑行为模式的框架.
- 使用来自现代病变症状映射的原则.
- 审查关于角性带损伤和相关缺陷的现有文献.
主要成果:
- AG损伤可能导致功能异质的症状,需要考虑特定的AG细分,连接性配置和相邻的病变范围.
- 要解释症状与其他大脑区域的重叠,需要了解AG的网络相互作用以及其他网络中的潜在功能冗余.
- 患者间的AG症状变化受中风恢复,人口统计,治疗和中风前功能解剖学的影响.
- 整合病变和功能神经成像数据是必不可少的,特别是注意到AG作为默认模式网络中枢的作用.
结论:
- 仅从病变数据中描述AG综合征是具有挑战性的,因为AG的功能及其网络相互作用的复杂性.
- 未来的研究应该采用多方面的方法,将详细的病变分析与基于网络的功能神经成像进行整合.
- 现代的病变-症状映射为更好地阐明AG相关认知缺陷的神经基础提供了一条前进的道路.
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