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核PKM2在折叠的G-四重复中结合了前mRNA,并揭示了它们的基因调节作用

Dimitrios G Anastasakis1, Maria Apostolidi2, Khalid A Garman3

  • 1RNA Molecular Biology Laboratory, NIAMS/NIH, Bethesda, MD, USA.

Molecular cell
|August 17, 2024
PubMed
概括

核PKM2结合RNA G-四重复,促进癌症基因表达. 抑制PKM2减少了癌细胞的入侵,这表明癌症进展的治疗点.

关键词:
在G-quadruplex中使用.G4 G4 G4 G4 的意思是什么?帕-克里普 (PAR-CLIP) 是一个在PKM2中,PKM2是PKM2.的RNA结合蛋白质.交叉连接和免疫沉降.转录后的基因调节.

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