用GI Genius人工智能内镜模块辅助的结肠镜检测多胞胎与常规结肠镜实践中的标准结肠镜相比 (COLO-DETECT):一个多中心,开放标签,平行臂,务实的随机受控试验
Alexander Seager1, Linda Sharp2, Laura J Neilson3
1Department of Research and Innovation, South Tyneside and Sunderland NHS Foundation Trust, South Tyneside District Hospital, South Shields, UK; Population Health Sciences Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
The lancet. Gastroenterology & hepatology
|August 17, 2024
概括
COLO-DETECT试验表明,GI Genius模块在结肠镜检查期间显著增加了腺瘤检测率. 这种计算机辅助检测 (CADe) 系统增强了多的识别,可能减少结直肠癌的发生率.
科学领域:
- 胃肠病学 胃肠病学
- 医疗技术 医疗技术 医学技术
- 在瘤学瘤学.
背景情况:
- 在结肠镜检查期间发现多的增加与结肠直肠癌发病率和死亡率的降低有关.
- COLO-DETECT试验评估了GI Genius智能内镜模块在常规结肠镜实践中的有效性.
研究的目的:
- 评估GI Genius模块在改善结肠镜检查期间检测聚的临床有效性.
- 将GI Genius (CADe辅助) 辅助的结肠镜与标准结肠镜进行比较.
主要方法:
- 一个多中心的,开放的,务实的随机对照试验,涉及2032名成年人在12家NHS医院.
- 参与者被随机分为1:1接受CADe辅助结肠镜或标准结肠镜.
- 主要结局是每次手术平均腺瘤;次要结局是腺瘤检测率.
主要成果:
- 与标准结肠镜相比,CADe辅助结肠镜显示每次手术的平均腺瘤 (1.56对1.21) 和腺瘤检测率 (56.6%对48.4%) 较高.
- 胃肠道天才模块显示,在腺瘤检测方面,调整后的发病率比为1.30和调整后的几率比为1.47.
- 两组之间不良事件发生率相似,没有报告GI Genius相关的不良事件.
结论:
- COLO-DETECT试验结果支持使用GI Genius系统来增强前恶性结肠直肠多的检测.
- 将GI Genius纳入常规结肠镜实践可以提高腺瘤检测率.
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