与乐普罗利德储存 (Lupron) 相关的过渡性突炎
Erica A Steen1, Susan A Phillips1,2
1University of California, San Diego, California, USA.
Endocrinology, diabetes & metabolism case reports
|August 17, 2024
概括
用性腺激素释放激素激动剂 (GnRHa) 治疗中部早期青春期可能会导致罕见的,严重的部疼痛和关节液. 切换到另一种GnRHa模拟物解决了症状,允许继续治疗.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 药理学 药理学是指药理学的学科.
- 类风湿病学 类风湿病学
背景情况:
- 中部早期青春期 (CPP) 需要及时干预,以防止不良结果.
- 淋巴激素释放激素激动剂 (GnRHa) 是CPP的标准治疗方法,通常具有有利的安全性.
- 罕见的局部和全身过敏反应已在使用GnRHa时报告.
研究的目的:
- 报告一个严重的关节疼痛和关节输液的病例,该病例是在CPP的DepotLeuprolide乙酸盐注射后出现的.
- 讨论疑似过敏反应对GnRHa治疗的管理.
- 为了突出转换到另一种GnRHa类似物继续治疗的选择.
主要方法:
- 一名6.6岁的女性确诊了CPP,接受了3个月的leuprolide酸盐注射.
- 记录了临床表现,诊断工作 (包括部超声波) 和治疗过程.
- 过敏咨询决定转换为另一个GnRHa模拟物 (Triptodur).
主要成果:
- 注射后6小时,患者出现了严重的右部疼痛,拒绝行走,以及轻度发烧.
- 部超声波显示了关节液体的积累,与炎症反应一致.
- 症状在两周内逐渐消失;随后的Triptodur治疗耐受良好.
结论:
- 虽然GnRHa疗法对CPP有效,但罕见的不良事件,如严重的关节反应可能会发生.
- 及时识别和管理,包括可能停止或更换代理,至关重要.
- 替代GnRHa配方可能为经历过敏反应的患者提供可行的选择.
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