肠道微生物群在MP/NP诱导的毒性中的作用
Yinping Pan1, Haojie Zhang1, Liancai Zhu1
1Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400030, PR China.
Environmental pollution (Barking, Essex : 1987)
|August 17, 2024
概括
微塑料和纳米塑料 (MP/NP) 破坏肠道微生物群,影响人类健康. 针对肠道微生物提供了新的策略,以减轻MP/NP毒性,并保护身体免受这些环境污染物.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 微塑料 (MP) 和纳米塑料 (NP) 是普遍存在的环境污染物,具有潜在的人类健康风险.
- 人类摄入MPs/NP主要通过饮食,影响胃肠道健康.
- 肠道微生物群在MP/NP毒性的作用尚不清楚.
研究的目的:
- 审查肠道微生物群在微塑料和纳米塑料引起的毒性中的作用.
- 探索肠道微生物群与MP/NP之间的相互作用.
- 通过向肠道微生物群来确定减轻MP/NP毒性的策略.
主要方法:
- 关于MP/NP暴露和人类健康的研究文献综述.
- 对MP/NP与肠道微生物群相互作用的研究分析.
- 综合了关于肠道微生物群在MP/NP中介毒性中的作用的发现.
主要成果:
- 国会议员/国民党员破坏肠道微生物群的稳态,并可能被它降解.
- MPs/NPs通过肠-器官轴 (肠-大脑,肠-肝脏,肠-肺) 引起直接的肠毒性和间接的系统性影响.
- 肠道微生物群在调解MP/NP毒性方面发挥着至关重要的作用.
结论:
- 肠道微生物群是了解和减轻MP/NP毒性的关键因素.
- 饮食干预,益生菌,益生菌和其他针对肠道微生物群的新方法显示出希望.
- 针对肠道微生物群的进一步研究对于制定有效的针对MP/NP污染的策略至关重要.
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