骨在能量代谢中的作用:侧重于骨质素
Cassandra Smith1, Xuzhu Lin2, Lewan Parker3
1Nutrition & Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia; Medical School, The University of Western Australia, Perth, Western Australia, Australia; Institute for Health and Sport (IHES), Victoria University, Melbourne, VIC, Australia; Australian Institute for Musculoskeletal Science (AIMSS), Victoria University and Western Health, St Albans, VIC, Australia.
Bone
|August 17, 2024
概括
来自骨的荷尔蒙,骨基因,影响葡萄糖的调节. 低碳氧化骨质卡尔辛 (ucOC) 对改善新陈代谢有希望,但对2型糖尿病 (T2D) 的临床意义需要进一步确认.
科学领域:
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
- 骨生物学 骨生物学 骨生物学
背景情况:
- 葡萄糖调节传统上集中在胰岛素和葡萄糖.
- 骨现在被认为是一种内分泌器官,产生骨质激素.
- 骨基因会影响肝脏,肌肉和脂肪组织中的葡萄糖代谢.
研究的目的:
- 审查骨源因素在全身葡萄糖调节中的作用.
- 专注于骨素 (OC) 和其他骨素,如RANKL,OPG,SCL和LCN2.
- 评估 osteokines 对2型糖尿病 (T2D) 的治疗潜力.
主要方法:
- 对体内,体外和体外研究的文献综述.
- 对转基因动物模型研究的分析.
- 检查人类临床数据,注意方法的变化.
主要成果:
- 骨质素 (OC),特别是低碳氧化OC (ucOC),可能充当激素.
- 在临床前的模型中,外源性ucOC的使用通常会改善葡萄糖代谢.
- 人类数据支持但不一致,突出了对标准化研究的需要.
结论:
- 骨衍生因素显著影响能量代谢.
- 有益的骨质激素包括ucOC和OPG;有害的包括RANKL和SCL.
- 对于T2D的骨质激素的临床相关性和治疗价值仍需得到确认.
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