农业河流系统中的抗生素耐药性动态:阐明传播机制和与之相关的水安全风险
Tong Chen1, Ziwei Wang1, Xiaohong Ruan1
1Key Laboratory of Surficial Geochemistry, Ministry of Education, Nanjing University, Nanjing 210023, China; School of Earth Sciences and Engineering, Nanjing University, Nanjing 210023, China.
The Science of the total environment
|August 17, 2024
概括
来自农业的抗生素耐药性基因 (ARG) 威胁到水安全. 靠近河流的耕地在水和沉积物中显著增加了ARG,由于移动遗传元素,沉积物中的风险更高.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 水的质量 水的质量
背景情况:
- 在农业中使用抗生素会增加河流系统的抗生素耐药性基因 (ARG) 通过便排放,威胁到水安全.
- 在受土地使用和季节影响的农业河流系统中,ARG的动态,传播和风险尚不清楚.
研究的目的:
- 系统地评估ARG在上层水和沉积物中的污染和传播.
- 研究土地利用空间规模和季节性变化对ARG动态和传输机制的影响.
主要方法:
- 使用元基因组测序来分析覆盖的水和沉积物样本中的ARG.
- 蒙特尔测试用于评估土地使用模式对ARG传播的影响.
主要成果:
- 覆盖的水具有更高的ARG多样性 (多药性耐药性),而沉积物则显示出更高的丰度 (硫胺耐药性).
- 水中的ARG动态对季节性变化比沉积物更敏感;微生物群调节水中的ARG,而移动遗传元素 (MGE) 推动沉积物中的ARG传播.
- 河岸5公里以内的耕地是关键因素,增加了MGE和营养,导致高耕地,特别是沉积物中的ARG增加了一倍,提高了水安全风险.
结论:
- 沉积物具有较高的抗生素耐药性风险,而不是由于不同的传播机制而覆盖的水.
- 农业用地,特别是靠近耕地,对ARG污染和传播产生重大影响,强调需要有针对性的控制措施.
- 了解农业流域的ARG动态对于制定确保区域水安全的战略至关重要.
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