药剂师领导的抗微生物药物管理计划在术后环境中的有效性:系统性审查和元分析
Lina Naseralallah1, Somaya Koraysh1, Bodoor Aboujabal1
1Pharmacy Department, Hamad Medical Corporation, Doha, Qatar.
Research in social & administrative pharmacy : RSAP
|August 17, 2024
概括
药剂师领导的抗微生物药物管理 (AMS) 计划显著改善了抗生素处方,并减少了外科手术场所感染 (SSI) 在外科手术期间. 为了优化这些干预措施,需要进一步进行高质量的研究.
科学领域:
- 药房实践 在药房实践.
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 抗微生物耐药性需要有效的抗微生物管理 (AMS).
- 术前设置对于预防手术部位感染 (SSI) 来说至关重要.
- 药剂师在AMS中的作用正在演变.
研究的目的:
- 评估药剂师领导的AMS干预措施的有效性.
- 评估对抗微生物使用和SSI率的影响.
- 描述药剂师在术后AMS中的角色.
主要方法:
- 11项研究的系统综述和元分析.
- 在PubMed,Embase和CINAHL数据库中进行搜索.
- 使用药剂师干预表征工具的描述元素提取数据.
- 使用Crowe批判性评估进行质量评估.
- 随机效应模型的元分析.
主要成果:
- 药剂师的角色包括教育,病房巡回,审计和指导方针制定.
- 在抗生素选择 (OR 4.29),施用时间 (OR 4.93) 和持续时间 (OR 5.27) 中观察到显著改善.
- 药剂师主导的AMS计划与SSI (OR 0.51) 的减少有关.
结论:
- 药剂师领导的AMS计划在优化抗菌素处方和减少SSI方面是有效的.
- 大多数纳入的研究质量中等.
- 需要进一步的高质量,理论衍生的干预研究来增强AMS策略.
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