血小板计数作为急性呼吸困难综合征的预后标志物
1Department of Intensive care unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, 310000, China, No 3 East Road Qingchun.
BMC pulmonary medicine
|August 17, 2024
概括
血小板计数 (PLT) 是急性呼吸困扰综合征 (ARDS) 患者死亡的重要预测指标. 较低的PLT水平与增加的死亡风险有关,突出显示PLT.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 急性呼吸困扰综合征 (ARDS) 是一种严重的疾病,死亡率高.
- 在ARDS患者中血小板计数 (PLT) 的预后作用仍然不完全理解.
研究的目的:
- 调查ARDS诊断的患者血小板计数 (PLT) 和死亡率之间的关联.
- 为了确定PLT是否作为ARDS结果的独立预后标志物.
主要方法:
- 来自MIMIC数据库的3207名ARDS患者的回顾性分析.
- 根据初始PLT,患者被分为四组:≤100,101-200,201-300和>300 × 10 9 / L.
- 卡普兰-梅尔生存分析和考克斯比例危险模型用于评估28天,60天和90天的死亡率.
主要成果:
- 血小板计数 (PLT) ≤100 × 109/L与较高的28天,60天和90天死亡率显著相关 (P<0.001).
- 多变量分析显示,较高的PLT组 (101-200, 201-300, >300 × 109/L) 与最低的PLT组相比,死亡率的调整危险比率明显较低.
- 这种关联在分析的大多数子组中是一致的.
结论:
- 血小板计数 (PLT) 是ARDS重症患者死亡率的独立预测指标.
- 较低的血小板计数表明ARDS患者的预后较差.
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