基因预测的脂质特征调解了叶酸和动脉样硬化之间的关联
Jie Qi1, Haoyu Wu1, Haichao Chen1
1Second Department of Cardiovascular Medicine, Shaanxi Provincial People' Hospital, Xi'an City, 710068, Shaanxi Province, People's Republic of China.
低叶酸 (FA) 水平与增加动脉样硬化 (AS) 风险有关. 这项研究证实了FAFA的存在.
科学领域:
- 遗传学和心血管疾病流行病学
背景情况:
- 动脉样硬化 (AS) 是心血管死亡的主要原因.
- 低叶酸水平与AS风险增加有关.
- 了解因果关系和调解因素对于预防至关重要.
研究的目的:
- 确定叶酸 (FA) 对动脉样硬化 (AS) 的因果作用.
- 量化脂质配置文件 (LDL-C,HDL-C,TG) 在FA-AS关系中的调解作用.
主要方法:
- 使用了两个样本的门德尔随机化 (MR) 研究设计.
- 采用来自IEU开放GWAS项目的全基因组关联研究 (GWAS) 数据.
- 进行了两步MR分析,以评估LDL-C,HDL-C和TG的调解.
主要成果:
- 基因确定FA水平显示与AS风险有保护性关联 (OR=0.623,P=0.018).
- FA水平与HDL-C (OR=1.358,P=0.031) 有正相关,与LDL-C (OR=0.956,P=0.023) 和TG (OR=0.929,P=0.003) 有负相关.
- LDL-C,HDL-C和TG分别占FA对AS总影响的3.00%,6.80%,4.40%,总计13.04%.
结论:
- 叶酸 (FA) 对动脉样硬化 (AS) 有潜在的因果保护作用.
- 脂质配置文件,包括LDL-C,HDL-C和TG,显著介导这种保护作用.
- 针对脂质水平的干预措施可能有助于减轻与低FA相关的AS负担.
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